cigarettes and indigestion How Cigarette Smoking Triggers Acid Reflux: The Mechanisms CAN SMOKING CAUSE GASTROESOPHAGEAL REFLUX

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(And that applies whether it's tobacco, marijuana, or whatever other addictive things you want to smoke.) So let's take the "addiction" part out of the picture

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However, another study on water-soluble and hexane-soluble extracts showed that the latter significantly induce MMP-1 gene expression 36 , suggesting that the insoluble compounds of cigarette smoke could also induce deleterious effects